As a relatively new construct which is gradually gaining more attention in Croatia, work engagement represents a positive aspect of job involvement and is usually being defined as a positive,fulfilling, work-related state of mind that is characterized by vigour, dedication, and absorption. Since work-engaged employees show inovative behaviours and initiative,proactively seek for the chance to demonstrate abilities and go beyond what is being expected from them, it seems useful to investigate some determinants of work engagement, especially the ones from the job demands-resources model, but some others, such as personal and family resources as well. Hence the aim of the conducted research was to determine relations between work engagement of the University teachers from three Croatian Universities and some predictors and outcomes which are important both for the employee as for theorganization he/she works for.As expected, results show that experienced meaningfulness of the work, experienced responsibility for work outcomes and knowledge of results are positively related to the components of work engagement. Moreover, core self-evaluations as a personal resource, and family harmony as a family resource also contribute to explanation of work engagement. In addition, the more vigorous and dedicated employees are, the more organization commitment they show. Practical implications of results along with some limitations of this study and suggestions for the further ones are being discussed.