Navigating the pandemic and isolation fueled by a desire to prevent the spread of the coronavirus disease made 2020 particularly challenging. As a result, people faced various risk factors that interfered with their daily lives. These include the separation from others, lack of physical contact, the influx of information coming from the media, and the uncertainty of the duration and the outcome of the situation that affected both the individual and the society as a whole. The presence of risk factors influenced individuals’ psychological well-being by introducing symptoms of stress, anxiety, and depression as unpleasant emotional symptoms. In dealing with an unfavorable situation, factors such as psychological resilience and coping strategies acted as protective factors. Due to the specific requirements of the isolation, people had to be creative in finding ways to deal with stressors coming from the environment and, since previous research has indicated the presence of positive effects of creative activities on psychological well-being, this research aims to determine the connection between activities that pertain to various domains of creativity and some of the psychological aspects such as anxiety, stress, depression, coping strategies and resilience during the isolation. The study involved 122 female and 17 male participants, 139 participants in total with an average age of 23,20 years (SD = 2,16). The sample is comprised of Croatian students, and all of the participants were examined with an online questionnaire. The questionnaire featured questions on the general demographic data, the Creative Achievement Questionnaire, the Coping Strategies Questionnaire, the Depression Anxiety and Stress Scale (DASS-21), and the Brief Resilient Coping Scale. The results have shown that people who usually engaged in creative activities in their daily lives have greater psychological resilience than people who did not engage in creative activities. Also, it has been shown that psychological resilience during the isolation period has been positively correlated with the frequency of performing these activities across all examined domains of creativity, except in sports, while unpleasant emotional symptoms have not been significantly correlated with activities in any creative domain. Hierarchical regression analysis has revealed a significant contribution of predictors of avoidance coping strategies and resilience to the criterion variable of unpleasant emotional symptoms.