Employed parents of children with developmental disabilities face numerous challenges in both of their life roles, family and work. However, research shows that engagement and acquisition of resources in one role can better the performance of the other role and that process is called role facilitation. Role facilitation can occur in two directions: work-to-family facilitation (WFF) and family-to-work facilitation (FWF). The aim of this research was to examine the contribution of sociodemographic and family characteristics, organizational characteristics and social support in the explanation of facilitation between work and family roles among mothers of children with developmental disabilities. The research was conducted as part of the project „Well-being of Employed Parents of Children with Developmental Disabilities“ (DZRDTR), funded by the University of Zadar. Data was collected through online questionnaires and the participants involved in this study were 425 employed mothers of children with developmental disabilities who had undergone official assessment. Hierarchical regression analysis shows a statistically significant contribution of factors from sociodemographic and family domain, organizational domain and social support in explaining both direction of facilitation. Specifically, higher level of education, a more severe degree of disability, a higher level of personal importance of career achievement, work in shifts, higher level of job satisfaction and higher level of social support at work significantly contributed to the higher levels of work-tofamily facilitation (WFF) among employed mothers of children with developmental disabilities. A larger number of children in the household, higher level of job satisfaction and higher level of family social support significantly contributed to higher levels of family-to-work facilitation (FWF) among employed mothers of children with developmental disabilities. Overall, factors from organizational domain contributed more to the explanation of WFF (27.6%) than FWF(12.4%). These results have practical implications in the form of planning and implementing adequate workplace interventions, as well as interventions that would help increase levels of social support in both environments in order to facilitate the functioning of parents of children with disabilities in both life roles, thereby improving overall well-being.