The use of opiates has probably been present since the very beginning of the devolopment of our species, and evidence of its use can be found in all parts of the world. People who pratciced the use of such opiates (psychoactive), were mostly very influential in society, especially in prehistoric times. These were shamans who left their mark on the very beginning of religion, art, technology and medicine. Sometimes opiates, were practiced only by shamans, and sometimes by a larger number of people or even the whole community. Regardless of the repressions throughhout history, especially with the arrival of Christianity, this practice of using psychoactive preparations has been preserved to this day. The latest medical studies of the impact of psychoactive drugs on human mind, support the theory that psychoactive drugs may even have had impact on the devolopment of our civilization.