The title of this work is: Nurses' interventions in the application of antipsychotics on patients with schizophrenia. It refers to the work of nurses and implementation of health care for these patients. The work will mostly handle schizophrenia and behavior of nurses during the health care. Schizophrenic patient is a person who has a distorted image of reality and can not distinguish the real from unreal experiences due to dysfunction of the brain (3). The disease occurs between the twenties and thirties (5). Schizophrenia is identified by characteristic symptoms. In the literature typical symptoms of schizophrenia sre known as "4A": autism, avolition (disorder) and affect (disorder) association (2). The symptoms of schizophrenia are divided on positive and negative symptoms. The disease usually occurs in episodes. Between episodes, in the period of remission with proper treatment, a person will have no symptoms of the disease. The re-emergence of disease is prevented by regular medication treatments. In this paper, I will describe the different types of schizophrenia and treatment options. All procedures related to nurse will be presented in the context of the implementation of intensive care, monitoring of patients and expertise in providing therapy. The diagnosis, objectives, intervention and evaluation in the process of health care will be also explained.