Objective: To assess professional exposure to blood-borne infections in health workers of the General and Veterans Hospital "Hrvatski ponos" Knin. Subjects and methods: Nurses and technicians, and doctors of the General and Veterans Hospital "Hrvatski ponos" Knin participated in the research. The total number of respondents was N=51, 47 nurses/technicians and 4 doctors. An anonymous survey questionnaire was used as a research instrument, which was taken from Assoc. Ph.D. prim. Roka Čivljak, MD. with written permission to use it. Results: 51 participants answered the anonymous questionnaire. As the most common exposure incident, respondents mentioned a puncture with a hollow needle (59 %). The majority of respondents experienced an exposure incident multiple times in their professional life (59 %) ranging from 2 to 10 times, median 4 times. 26 % of respondents never reported the experienced incident, 37 % reported it every time, and sometimes 28 % of respondents out of a total of 46 respondents who experienced an incident. Furthermore, respondents estimate the highest probability of infection from hepatitis C (50 %), followed by HIV infection (40 %) and as the lowest probability of infection, they state the possibility of infection from hepatitis B (30 %). Conclusion: From the conducted research, it can be concluded that the nurses/technicians and doctors of the General and Veteran Hospital "Hrvatski ponos" Knin are professionally exposed to blood-borne infections. Conducting additional training on treatment procedures in case of injuries and raising awareness of the importance of reporting exposure incidents will reduce the risk of infection of health care workers from blood-borne infections.