The occurrence and treatment of postoperative nausea and vomiting are gaining importance due to the great impact on the delay of discharge and hospital readmission. Postoperative nausea and vomiting also strongly contributes to the patient's unpleasant experience and thus to the quality of postoperative recovery. There are numerous factors such as individual, anesthesiological and surgical factors that influence nausea and vomiting in the perioperative period and should be evaluated on time. For the prophylaxis and treatment of postoperative nausea and vomiting, numerous antiemetics are used, and their use depends on the existence of certain risk factors in the patient. Considering the lack of literature related to measuring the quality of postoperative recovery with the help of the QoR 15 questionnaire (English Quality of Recovery) after gynecological procedures, the aim of this work was to determine the incidence of postoperative nausea and vomiting, the frequency of use and the success of antiemetic pharmacological prophylaxis in patients scheduled for gynecological operations (open or laparoscopic hysterectomy, adnexectomy, removal of ovarian cysts, laparoscopic myomectomy,vaginal hysterectomy and anterior vaginal plastic) at the Department of Gynecology and Obstetrics in Zadar General Hospital from February 1st 2022 to July 1st 2022 and determine whether there is a statistically significant difference in the quality of postoperative recovery measured 24 hours after the procedure with the QoR 15 questionnaire between patients who received antiemetic prophylaxis compared to those who receive antiemetic therapy after the procedure. The research was conducted on 67 subjects who underwent gynecological surgical procedures and we came to the result that 26 (39%) subjects had nausea and vomiting during the first 24 hours after the procedure. A total of 38 (47%) subjects received antiemetics for prophylaxis and/or treatment. A total of 38 subjects received antiemetics. Subjects who received an antiemetic before and during the procedure 21/38 compared to those who received it after the procedure for therapeutic purposes 17/38, rated the enjoyment of food significantly better (P = 0.03), rated the support of department doctors as better and nurses (P = 0.008), and their nausea and vomiting (P = 0.001), as well as the overall assessment of the quality of postoperative recovery, were significantly lower compared to subjects who received antiemetic received after the procedure for therapeutic purposes (P = 0.02). In conclusion, the quality of postoperative recovery depends on the success of antiemetic prophylaxis, which is not sufficient in our institution. Despite the progress of anesthesia, it can be said that postoperative nausea and vomiting remain a "big little" problem.