Ulcerative colitis is an inflammatory disease of the large intestine, particularly of the rectosigmoid region, characterised by multiple surface ulcerations, in which the phases of remission and exacerbation alternate chronically. Chronic ulcerative colitis can affect only rectum and extends to further parts of the colon so that the patient may have inflammatory changes from proctitis to pancolitis. It was recognized as a non-bacilar dysentery entity in 1859 (1). The incidence of ulcerative colitis at the world level ranges from 0.5 to 24.5 cases per 100,000 inhabitants, and its occurrence is more frequent in developed countries. The number of new patients in Croatia is approximately 11 cases per 100,000 inhabitants (1). About 15% of the cases of ulcerative colitis of the initial manifestation occur within the first twenty years of life, although the peak of the incident is between 20 and 30 years (2). UK is a consequence of an abnormal reaction of intestinal mucosa under various conditions, the basic of which are: hereditary - constitutive, environmental and immunological factors. In advanced stages, local and systemic complications may occur, the most severe being perforation, cancer and massive bleeding (2). Depending on the activity, localization and spread of the disease, we choose the best treatment appropriate to the patient's problems. Basic procedures include pharmacological, non-pharmacological and surgical treatment. With treatment we want to achieve a correction of nutritive status, reduce inflammation and ensure rest in the intestines. The medicines most commonly used in this pathology can be reduced to five basic categories: corticosteroids, aminosalicylates, immunosuppressors or immunomodulators, anticholinergics, and biological therapy. (3). UC is a disease that significantly impairs the quality of life, with the role of a nurse in providing autonomy and support so that patients have a sense of control over their own disease, and the ability to manage their own condition by providing treatments that minimally interfere with theirs. Sister care is aimed at alleviating symptoms and minimising treatment complications, and reducing anxiety by maintaining emotional balance (4).