This paper presents events directly and indirectly related to the Imotski and Imotski's region from the end of the 14th to the end of the18th century. It is started from the reign of the various rulers under which rule Imotski was, that period lasts from the death of the Croat-Hungarian king Ludovik in 1382 to the fall of Imotski with its region under Ottoman rule in 1493. The paper highlights the most important persons for this period, followed by church circumstances and the beginning of the Ottoman penetration toward Imotski. During the Ottoman rule of Imotski and surrounding places, key events, migrations, ecclesiastical circumstances and administration are presented. In 1717 Imotski came under the Venetian rule, which was confirmed by the Treaty of Passarowitz in 1718, and under the same rule Imotski remains until the collapse of the Venetian Republic in 1797. For the duration of this reign, this paper shows the basic features of the administration, the church position and the state of the population in Imotski and its surroundings.