Anatomically modern humans came to Europe about 45,000 years ago with them begins the period of the Upper Paleolithic. The Upper Paleolithic is marked by the climate change and the spread of ice caps that led to the withdrawal of the forests and the increase of the deserted areas. Along with the new industry, there are cave and figurative arts and more burials. After the last glacial maximum, the temperature gradually increased and the ice caps started decreasing , causing sea levels to rise and changes in flora and fauna affecting the hunting and gathering communities at that time. On Eastern Adriatic, Epigravettian culture is distinguished as the final culture of the Upper Paleolithic, which transposes its foundations in the form of lithic objects, personal ornaments and settlement aspects into the cultural period of Mesolithic. The Mesolithic begins with the geological period of holocen and is marked by the rising of sea level on the Adriatic. The novelties in Mesolithic are the occurrence of geometric lithic objects , the lesser processing of lithic objects and, in relation to the previous period, the greater role of marine animals in the diet of hunter -gathering communities. Changes can be observed on Adriatic sites such as Vlakno, Vela Spila and Pupića cave, and from the sites in the hinterland Crvena Stijena.