Power has been an interesting concept for many scholars, especially in the field of sociology and philosophy. It was usually considered negative and destructive, used to alter people‟s decisions and goals. More traditional explanations viewed power as something to be held and fought for whereas modern approaches accept the idea of limited human ability to change already built structures. The Foucauldian notion of power explains it in relation to knowledge and total institutions as places where power with the help of knowledge is best practiced. The main role of prison as a total institution is to accept and internalize the socially accepted behavior so that normalization could take place. In popular culture, psychotic individuals are considered abnormal and the phenomenon of a psychopath serial killer is prominent in literature, movies, and TV series. The aim of this thesis paper is to examine the subversion of power that occurs in a relationship between serial killers and the police in the process of gathering knowledge. The theoretical background of the paper is Michel Foucault‟s critical theory. The focus is on the dynamics of the relationship between characters of agents and killers from Thomas Harris' novels Red Dragon, The Silence of the Lambs, and Hannibal and the TV series Mindhunter. The core of the analysis will be the representation of the power play between agents Starling, Graham, Holden, and Tench and serial killers Hannibal Lecter and Edmund Kemper.