Severe form of acute pancreatitis is the third and most severe stage of acute pancreatitis. The most common causes of acute pancreatitis are cholelithiasis and alcoholism. The development of severe inflammation can occur up to several hours after the patient's admission, and the reason for this is the development of a strong systemic inflammatory response. Due to disease progression causing multiorgan failure, about 50% of patients die within two weeks. Patients are of poor health with severe local and/or systemic complications present. Hypotension, metabolic disorders, sepsis and septic shock, and multiorgan failure are present as well. As for the local complications, the most severe are necrosis and infectious necrosis of the pancreas. Acute respiratory distress syndrome usually requires mechanical ventilation. Severe inflammation of the pancreas is characterized by the presence of tissue necrosis, and possible infectious necrosis which further complicates treatment and increases mortality. As it is a complex disease, a multidisciplinary approach during diagnosis and treatment is crucial. Serum amylase and lipase values, CRP and procalcitonin, as well as CT abdominal imaging are most commonly used in diagnosis as the gold standard for confirming the diagnosis and local complications. It is very important at the very beginning of treatment to assess the severity of the disease. The most commonly used are the Ranson criterion, the APACHE II scoring system, the Balthazar scoring system based on the CT image, and the BISAP index as well as the SOFA scoring system. The goal of supportive therapy is aimed at limiting and preventing further local and systemic complications, while surgical treatment is not always indicated. It is performed by laparotomy with necrectomy. As part of a multidisciplinary team, the medical technician is obliged to continuously assess the hemodynamic status of the patient, apply the prescribed therapy and timely inform the doctor about the deterioration of the patient's clinical features.