This paper seeks to present the socio-political conditions that characterized Šibenik as a city and diocese during the 17th century, which influenced the development of the sacred interior of the Church of St. Francis in Šibenik. During this period, the Venetian-Turkish wars were fought, and it was a time of accepting and implementing the decrees of the Council of Trent. The aim was to renew liturgical practices and organize church interiors. As a result, churches were equipped with liturgical furnishings that reflected both the state of society and the new liturgical practices. With a large number of Franciscan commissions from various masters, the interior of St. Francis church was furnished in a new Baroque style in the 17th century. Unlike the Franciscans, the Dominicans of Šibenik played a lesser role as patrons. This is as evidenced by donations from noble families and other members of society who contributed to the decoration of their churches and monasteries. Therefore, the Church of St. Francis in Šibenik was exclusively infused with the style inherited by the Franciscans during the 17th century, reflecting the artistic expression of the workshops and masters they favored. The furnishing of the interior lasted throughout the 17th and 18th centuries. Notably, there are four wooden carved gilded altars from the Venetian workshop of Ridolfi, adorned with altar paintings by the Venetian painter Matteo Ponzone. There is also a carved wooden ceiling decorated with panels created by the Venetian workshop of master Giambattista Volpato. This paper analyzes the commissions and the interior furnishings that have been preserved to this day in the context of the artistic and cultural scene of Šibenik and Dalmatia during that time. Additionally, the interior furnishings are analyzed in parallel with other works and achievements of the masters who created them. Among these, the most notable name is Matteo Ponzone, whose works in St. Francis Church are considered some of the highest-quality artistic achievements of the post-Tridentine period.