Multiple sclerosis is an autoimmune, chronic neurodegenerative disease of the central nervous system that significantly negatively impacts the quality of life of affected individuals. The disease is of unknown origin and primarily affects younger people, with women being more frequently affected. There is no specific cure for this disease, but its symptoms, which range from mild to severe, can be managed. If left untreated, these symptoms can lead to cognitive and physical disability in the early stages of the disease. The clinical presentation and forms of the disease vary, characterized by the occurrence and remission of neurological disturbances— ranging from temporary symptom relief to full recovery, but also to severe disease progression. Quality of life is a crucial concept for affected individuals, particularly in the context of chronic illnesses. This review paper focuses on the key determinants of quality of life in patients with multiple sclerosis. It also examines existing and emerging non-pharmacological treatment methods that directly and positively impact the quality of life of individuals affected by multiple sclerosis. The aim of the paper is to explore the differences between past, current, and future approaches to the assessment and treatment of specific symptoms of multiple sclerosis that significantly affect quality of life, as well as the role of nurses and technicians in this process.