The topic of this thesis is the state of the industrial sector and the vision of reindustrialisation of Osijek in the 21st century. The city of Osijek is located in the Osijek - Baranja county and covers an area of 174.98 km2. According to the 2011 census, Osijek is the fourth largest city in Croatia, with 108 048 inhabitants. This thesis analyzes the development phases of the industry in Osijek, the factors of the industrial sites and the reindustrialisation models. The purpose of this paper is to analyze the processes of industrial development in different phases and the current situation of the industry. In addition, factors such as industrial site, industrial zone, entrepreneur support institutions, and both existing and potential reindustrialization models were analyzed, including: the Strategy for the Development of Osijek as a Smart City by 2020, the Smart Industry Development Strategy, the Triple and Quadruple Helix Model, and Industry 4.0. This thesis quotes sources from scientific literature as well as sources about Osijek’s industry. By analyzing statistical data on the number and structure of employees, the number of companies, the index of industrial production volume, tables and diagrams were created. The ArcGIS software was used to create thematic maps that show the spatial coverage of the city of Osijek, including the construction and closure of factories, their transformation, and Osijek's industrial zones. Through field studies, a portion of the photo documentation was collected, while interviews were used to examine the state of the industry after World War II. The industrial development of Osijek was represented by a SWOT analysis. At the end of the thesis, all three hypotheses were accepted. Statistics on the number of employees prove that the food industry is Osijek's most developed industry. Favorable location factors and Osijek's traditional status as an agricultural region have maintained production in the food industry. An analysis of the cartographic representations revealed that since the Second World War, the industry has gradually moved from the center to the outskirts of the city. Industrial zones built on the outskirts of the city also prove the relocation of industry. The economic development of Osijek is possible through various models of reindustrialisation. Thanks to the city's strategy Osijek 2014 - 2020 created by the Triple Helix model, new industrial zones were built and targets for reindustrialization were set. The business incubators in Osijek promote reindustrialisation by setting up small and medium-sized enterprises.