INTRODUCTION: In modern medical practice, protective isolation measures are becoming increasingly important in the control and prevention of infections. Nurses play a central role in this process, from understanding key concepts such as the vogralic chain, defining protective isolation, and applying standard operating procedures. OBJECTIVE: The objective of this paper is to describe and explain in detail the importance of the role of nurses in the implementation of protective isolation measures. DISCUSSION: The paper examines in depth the role of nurses in protective isolation, including the use of protective equipment, hygiene, disinfection, procedures, and protocols. The importance of education and communication is also explored, both with patients and their families and within the medical team. The strategic framework for practice improvement is considered with particular attention to the challenges of social isolation and the importance of education and information. CONCLUSIONS: Nurses are critical in implementing isolation interventions, not only because of their technical expertise, but also because of their communication and education skills. It is clear from this paper that their role is essential for successful infection control and prevention, and that their education and communication with patients and the team play a key role in achieving this goal.