Psychoactive substances are substances that affect the way we perceive things. They change mood and behavior. There are many types of psychoactive substances, and they are most often divided according to the mode of action on: central nervous system depressants, central nervous system stimulants, hallucinogens and others. With long-term use of a certain psychoactive substance, a person develops tolerance, and thus physical dependence on that substance. Withdrawal syndrome occurs if the dose is reduced or discontinued. Depending on the type of psychoactive substance the person has been addicted to, different withdrawal symptoms occur, which can range from mild to severe. There are several methods of treating abstinence crises. Treatment can take place in the patient's home or through state and non-governmental institutions. Amphetamines are one of the most commonly used stimulants in the world. Their use leads to increased secretion of dopamine in the brain. Stopping taking amphetamines is not life-threatening, but people describe it as a very difficult and uncomfortable process. With amphetamine withdrawal syndrome, a person may develop health complications that affect their quality of life. This is why the role of the nurse in caring for patients in an abstinence crisis is very important. With her knowledge, communication and skills, the nurse helps the patient to alleviate the symptoms of withdrawal and in life after the abstinence crisis. The aim of this paper is to describe substance use disorder, addiction, distribution of psychoactive substances, abstinence crisis in general, amphetamine abstinence crisis and the task of the nurse.