This thesis deals with the relations between the Republic of Dubrovnik and the Ottoman Empire in the period from the great earthquake that hit Dubrovnik until the final establishment of the borders between the Republic of Dubrovnik, Porte and the Venetian Republic in 1721. Given the numerous war conflicts on European soil during the 17th century, the work begins with an account of the political situation within which the relationship between the Republic and the Porte developed. The staple of their relationship was the economy, i.e., its most prominent branch - trade. The mediating role that Dubrovnik played in the relationship between the West and the East enabled him 'freedom' until the beginning of the 19th century. Such parole was paid to the sultan by the people of Dubrovnik every year in the form of a tribute. Considering that the year 1667 was crucial for the economy of the Republic of Dubrovnik, the paper especially emphasizes the economic ties with Porto before and after the earthquake. The period from 1667 to 1721 was marked by numerous military conflicts between the Porte and the Venetian Republic, consequences of which the Republic of Dubrovnik felt as well. Territorial redrawing, which was one of the topics of the peace agreements in Srijemski Karlovci in 1699 and in Požarevac in 1718, showed all the power of Dubrovnik diplomacy. In addition, the paper deals with the everyday life of the population at the crossroads of the Republic of Dubrovnik and the Ottoman Empire, and special emphasis is placed on interfaith relations. Given the extremely important geostrategic position of the Republic of Dubrovnik, its relationship with the Port was carefully observed by Western European countries. Thus, the paper gives a view of the Dubrovnik-Ottoman relations from the perspective of the Papal State, the French, and the Venetian Republic, since each of these states was in its own way connected with the Republic of Dubrovnik. The well-known Dubrovnik diplomacy, which was one of the foundations of Dubrovnik-Ottoman relations, stands out as the backbone of the entire work.