The aim of the final work is to show the development of printing and book publishing in Split until the end of the 19th century. The most important persons and centers of printing in the world context and in Croatia are presented, and Gutenberg's printing press is highlighted as the beginning of the development of printing. Printing spread in large European cities, of which Venice stands out, in which numerous Croatian printers operated. In the area of Split, the beginning of printing is considered to be 1812, when Giovanni Demarchi from Dignan opened the first printing house. The emergence of bookstores in Split influenced social, political and cultural activities, the result of which was the strengthening of bookstore power. An example is the Morpurgo bookstore, which encouraged patriotism during the Croatian national revival. After a historical overview, in the research part of the work, activities related to printing and book publishing in Split were compared with the emergence and development of printing and book publishing in other parts of Croatia. Split's contribution to Croatia's cultural development is expected, especially during the Croatian national revival. The results of the research indicate the later development of printing and book publishing in Split in relation to the rest of Croatia, largely due to the dominance of the Venetian government, which prevented ties with Bansko Croatia. Also, due to the fact that most of the books are printed in Italian, it is not possible to determine with certainty where they are printed.