DM is a disease that affects the body's ability to produce or effectively use insulin to control blood glucose levels. Too much glucose in the blood over a long period of time can cause damage in many parts of the body. DM can damage the heart, kidneys, skin and blood vessels, and it also damages the small blood vessels in the eye. Research shows that about 90% of vision loss caused by diabetes can be prevented. Early detection is key. People with diabetes need annual eye and skin exams even before signs and symptoms of damage appear. Diabetic eye disease is a term for several eye problems that can all be a result of diabetes. Diabetic eye disease most often includes diabetic retinopathy, with consequent vision loss. DM is the most common endocrinological disease, which affects 8.3% of the population, and skin changes are seen in 79.2% of patients with DM. Pathogenesis is associated with hyperglycemia and insulin dysfunction, either directly or through damage to the vascular, neurological, or immune systems. Skin changes in DM are divided into changes related to metabolic, vascular, neurological and immunological abnormalities, changes of unknown etiology in association with diabetes mellitus, and glucagon syndrome. syndrome. The first mentioned include acantois nigricans, scleroderma diabeticorum, eruptive xanthomas, bacterial and fungal infections, diabetic ulcer. Skin changes in association with diabetes mellitus of unknown etiology are necrobiosis lipoidica, granuloma annulare, diabetic dermopathy, acquired perforating dermatoses. Considering the complexity of the disease, a multidisciplinary team participates in diagnosis and therapy, and we will show the important role of the nurse.