Aim: The aim of the research is to question the attitudes and knowledge on vaccination against COVID-19 disease among the students and teachers of the Medical School in Šibenik. Respondents and methods: The total of 282 respondents took part in the research, out of which 247 students and 35 teachers as well. The students from the following courses participated in the research: nurse/medical technician of general care, pharmaceutical technician, physiotherapist and laboratory technician. The questions in the questionnaire reffered to the intentions and behaviour of participants related to vaccination against COVID-19 disease and the factors wich influence their decision on accepting, indecisiveness or rejecting vaccination. Results: The results suggest that the teachers have more knowledge and more positive attitude and confidence in vaccation against COVID-19 disease than the students. Pandemic has affected respondents mental health, and students knowledge on COVID-19 pandemic doesn't differ with the courses they attend. Younger respondents are less ready to get vaccinated. The respondents use different sources to get information about vaccines. Conclusion: The school as an institution has to organize additional education, lessons and expert tuition aiming to improve attitudes and knowledge of COVID-19 pandemic.