Introduction: Gastrointestinal bleeding is indicated by the appearance of blood in the digestive system. Bleeding can be visible (manifest bleeding) or hidden (occult bleeding) which may originate from the upper or lower digestive tract. Clinical manifestations of gastrointestinal bleeding depend on the intensity and location of bleeding. Bleeding is manifested by hematemesis, melena and haematochezia As one of the most common emergencies, acute gastrointestinal bleeding requires early detection and access to the specific therapeutic methods. Objective: To show a nurse's role in the patients care with bleeding from the upper part of the digestive system, to explain in more detail the issues that occur by pointing to the symptoms and signs of those issues. The objective is also to show the results of statistical processing of data of patients who were treated in 2019 at the Department of Intensive Internal Care, General Hospital of Zadar with a diagnosis of bleeding from the upper part of the digestive system. Results: The analysis of available statistical data has shown that 87 patients with a diagnosis of acute upper gastrointestinal bleeding were hospitalized at the Department of Intensive Internal Care, of which 63 were men and 24 were women. The middle age of patients was 70.02 years. The most common site of bleeding, with manifestation of 40%, is occupied by duodenal ulcer. It is followed by gastric ulcer (33%), oesophageal varices and gastritis (8%) and gastric varices with manifestation of only 1%. Hospitalization lasted 8.8 days with a mortality rate of 9.2%. Discussion: Nursing care seeks to recognize alarming symptoms and signs in a timely manner, and to prevent complications and the development of haemorrhagic shock. Conclusion: Male sex, older age, the presence of comorbidities and lifestyle are factors of risk for the development of the illness. Patients with gastrointestinal bleeding require early detection of the region which is responsible for bleeding, achieving hemodynamic stability, stopping the bleeding and preventing re-bleeding episodes.